Day 26 of Andrew Plotkin's My Very Secret MacOSX Diary (no permalink, just scroll to the end) provides a simple Perl recipe for killing the QuickTime Pro ad that appears every time you start QuickTime.
Apropos of this, Plotkin writes:
One day I will be having lunch with Steve, and I will say "Hey, Steve, I love your computers. I own five of them. Never use anything else. BTW, remember those QuickTime Pro pop-up ads?" Then I will push his boiling-hot coffee off the table onto his crotch, and walk away.